Neuroglobin

Neuroglobin (Ngb) is a protein that in humans is encoded by the NGB gene. It is a member of the globin family and is predominantly expressed in the brain and retina. Neuroglobin has been found to bind oxygen in a manner similar to myoglobin and hemoglobin, and may play a role in oxygen supply to nerve cells.

Structure

Neuroglobin is a monomeric protein with a molecular weight of approximately 17 kDa. It is composed of 151 amino acids and has a structure similar to other members of the globin family. The protein has a characteristic heme group that allows it to bind oxygen.

Function

The exact function of neuroglobin is still under investigation. However, it is known to bind oxygen and it is thought to play a role in oxygen supply to nerve cells. Some studies suggest that neuroglobin may also have a neuroprotective role, helping to protect nerve cells from damage due to lack of oxygen or other stresses.

Clinical significance

Alterations in neuroglobin expression have been associated with several neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. Further research is needed to fully understand the role of neuroglobin in these conditions.

See also

• Globin
• Hemoglobin
• Myoglobin

References

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