Indanidine

Indanidine is a vasodilator and antihypertensive drug. It is a selective alpha-2 adrenergic receptor agonist that is used to treat hypertension.

Mechanism of action

Indanidine works by stimulating alpha-2 adrenergic receptors in the brain, which decreases sympathetic nervous system activity and reduces blood pressure. It also has a direct relaxing effect on vascular smooth muscle.

Uses

Indanidine is used to treat hypertension. It may be used alone or in combination with other antihypertensive drugs.

Side effects

Common side effects of indanidine include dizziness, fatigue, and dry mouth. Less common side effects include depression, sleep disturbances, and sexual dysfunction.

Contraindications

Indanidine is contraindicated in patients with severe bradycardia, heart block, or heart failure. It should also be used with caution in patients with a history of depression or other psychiatric disorders.

Interactions

Indanidine may interact with other drugs, including other antihypertensive drugs, antidepressants, and sedatives. It may also interact with alcohol, increasing the risk of dizziness and fainting.

Pharmacokinetics

Indanidine is rapidly absorbed after oral administration and has a half-life of about 12 hours. It is metabolized in the liver and excreted in the urine.

See also

• Vasodilator
• Antihypertensive drug
• Alpha-2 adrenergic receptor
• Hypertension

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