Policosanol

Policosanol is a chemical compound derived from sugar cane, specifically from the wax of the sugar cane plant. It is a mixture of long-chain alcohols, the most prevalent of which is octacosanol. Policosanol has been studied for its potential effects on cholesterol levels, though results have been mixed.

History

Policosanol was first isolated and identified in the 1990s by Cuban scientists. It was initially marketed as a natural supplement for lowering cholesterol levels. However, subsequent research has produced conflicting results regarding its effectiveness.

Chemical Composition

Policosanol is a mixture of long-chain alcohols. The most prevalent alcohol in the mixture is octacosanol, which makes up about 60-70% of the total composition. Other alcohols present in smaller amounts include triacontanol, hexacosanol, and dotriacontanol.

Uses and Effects

Policosanol is most commonly used as a dietary supplement with the aim of lowering cholesterol levels. Some studies have suggested that it may be as effective as statins in this regard, but these findings have not been universally accepted.

In addition to its potential cholesterol-lowering effects, policosanol has also been studied for its potential effects on platelet aggregation, claudication, and lipid peroxidation. However, more research is needed in these areas.

Safety and Side Effects

Policosanol is generally considered safe for most people when taken by mouth in doses of up to 20 mg per day. However, it can cause side effects such as skin rash, headache, insomnia, and weight loss. People with a bleeding disorder or who are taking blood-thinning medications should use policosanol with caution.

See Also

• Cholesterol
• Dietary supplement
• Octacosanol

References

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