GHRP-6

GHRP-6 or Growth Hormone Releasing Peptide-6 is a synthetic met-enkephalin analogue. It is one of several synthetic met-enkephalin analogues that include unnatural D-amino acids, were developed for their growth hormone (GH) releasing activity and are called GH secretagogues. They lack opioid activity but are potent stimulators of GH release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through action at a completely different receptor. This receptor was originally called the GH secretagogue receptor, but now it is referred to as the ghrelin receptor.

Mechanism of action

GHRP-6, similar to other peptides, is most effective synergistically when administered with GHRH or a GHRH analogue. The increase in growth hormone secretion produced by GHRP-6 is inhibited by the central nervous system somatostatin. GHRP-6 also promotes food intake by stimulating hunger and helps increase energy metabolism.

Side effects

GHRP-6 can cause a range of side effects, such as a significant increase in hunger due to a stimulating effect on the ghrelin system, which is responsible for the sensation of hunger. Other potential side effects include: fluid retention, tingling and numbness, decreased insulin sensitivity, and decreased glucose tolerance.

See also

• Growth hormone
• Ghrelin
• Met-enkephalin

References

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