Traditional serrated adenoma

Traditional Serrated Adenoma (TSA) is a type of polyp found in the colon and rectum. It is considered a precursor to colorectal cancer, particularly the subtype known as microsatellite instability-high (MSI-H) colorectal cancer.

Overview

Traditional serrated adenomas are rare, accounting for less than 1% of all colorectal polyps. They are typically found in the distal colon and rectum, and are more common in women and older individuals. The average age at diagnosis is 60 years.

Pathology

Traditional serrated adenomas are characterized by a serrated or "saw-tooth" appearance under the microscope. They also have distinctive histological features, including eosinophilic cytoplasm, elongated nuclei, and prominent nucleoli.

Clinical Significance

Traditional serrated adenomas are considered precursors to colorectal cancer, particularly the subtype known as microsatellite instability-high (MSI-H) colorectal cancer. However, the exact risk of progression to cancer is not well established.

Diagnosis

The diagnosis of traditional serrated adenoma is made by colonoscopy and biopsy. The polyps are typically small and flat, making them difficult to detect.

Treatment

The treatment for traditional serrated adenoma is endoscopic removal. This can be done during a colonoscopy.

See Also

• Adenoma
• Colorectal cancer
• Colonoscopy
• Microsatellite instability

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