Mestranol/hydroxyprogesterone acetate

Mestranol/hydroxyprogesterone acetate

Mestranol/hydroxyprogesterone acetate is a combination medication used for hormonal contraception. It contains two active ingredients: mestranol, which is an estrogen, and hydroxyprogesterone acetate, which is a progestin. This combination provides effective contraception by preventing ovulation, thickening cervical mucus to inhibit sperm penetration, and altering the endometrium to prevent implantation.

Composition

Mestranol/hydroxyprogesterone acetate is available in the form of oral tablets. Each tablet contains a fixed dose of mestranol and hydroxyprogesterone acetate. The specific dosage may vary depending on the brand and formulation.

Mechanism of Action

Mestranol, as an estrogen, works by inhibiting the release of follicle-stimulating hormone (FSH) from the pituitary gland. This prevents the development and maturation of ovarian follicles, thereby preventing ovulation. Additionally, mestranol increases the thickness of cervical mucus, making it difficult for sperm to penetrate the cervix.

Hydroxyprogesterone acetate, as a progestin, acts by suppressing the secretion of luteinizing hormone (LH) from the pituitary gland. This further inhibits ovulation and helps maintain a consistent contraceptive effect. Hydroxyprogesterone acetate also alters the endometrium, making it less receptive to implantation.

Indications

Mestranol/hydroxyprogesterone acetate is primarily indicated for the prevention of pregnancy. It is a reliable and convenient method of contraception when used correctly. However, it does not protect against sexually transmitted infections (STIs).

Dosage and Administration

The dosage and administration of mestranol/hydroxyprogesterone acetate may vary depending on the specific brand and formulation. It is important to carefully read and follow the instructions provided by the manufacturer or healthcare professional.

Typically, the medication is taken orally once daily, preferably at the same time each day, for 21 consecutive days. This is followed by a 7-day interval without medication, during which withdrawal bleeding usually occurs. After the 7-day interval, a new pack is started, regardless of whether bleeding has stopped or not.

Side Effects

Common side effects of mestranol/hydroxyprogesterone acetate may include nausea, breast tenderness, headache, breakthrough bleeding, and mood changes. These side effects are usually mild and transient, resolving on their own. However, if they persist or worsen, it is important to consult a healthcare professional.

Rare but serious side effects may include blood clots, liver problems, and allergic reactions. Seek immediate medical attention if you experience symptoms such as severe abdominal pain, chest pain, shortness of breath, yellowing of the skin or eyes, or a severe allergic reaction (e.g., rash, itching, swelling).

Precautions

Mestranol/hydroxyprogesterone acetate should not be used in certain conditions, such as pregnancy, breastfeeding, history of blood clots, liver disease, or certain types of cancer. It is important to disclose your complete medical history and any current medications to your healthcare professional before starting this medication.

Smoking increases the risk of serious cardiovascular side effects associated with hormonal contraceptives. Therefore, it is generally advised to avoid smoking while using mestranol/hydroxyprogesterone acetate.

Interactions

Mestranol/hydroxyprogesterone acetate may interact with certain medications, including anticonvulsants, antibiotics, antifungals, and herbal supplements. These interactions can affect the efficacy of the contraceptive or increase the risk of side effects. It is important to inform your healthcare professional about all medications you are taking before starting this medication.

Conclusion

Mestranol/hydroxyprogesterone acetate is an effective combination medication for hormonal contraception. It provides reliable contraception by preventing ovulation, thickening cervical mucus, and altering the endometrium. However, it is important to use this medication as directed and consult a healthcare professional for personalized advice.

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