IRF8

IRF8 (Interferon Regulatory Factor 8) is a protein that in humans is encoded by the IRF8 gene. It is a member of the interferon regulatory transcription factor (IRF) family. IRF8 has been found to be critically involved in the development of the immune system and the regulation of immune cell function.

Function

IRF8 is expressed in lymphocytes and monocytes, two types of immune cells that are critical for immune response. It functions as a transcription factor, which means it helps control the expression of other genes. Specifically, IRF8 regulates the differentiation and function of macrophages and dendritic cells, both of which are important for initiating immune responses.

Clinical significance

Mutations in the IRF8 gene have been associated with the development of various diseases. For example, a specific mutation in IRF8 has been linked to the development of chronic myelogenous leukemia, a type of blood cancer. Other studies have suggested a role for IRF8 in autoimmune diseases, including multiple sclerosis.

Research

Research on IRF8 has provided valuable insights into the workings of the immune system. It has also opened up new avenues for the development of treatments for diseases such as cancer and autoimmune disorders.

See also

• Interferon Regulatory Factors
• Transcription factor
• Immune system
• Chronic myelogenous leukemia
• Multiple sclerosis

References

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External links

• GeneCards - IRF8
• NCBI - IRF8

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