Ethadione

Ethadione is an anticonvulsant that was used to treat various types of seizure disorders. It was withdrawn from the market due to its adverse effects on the fetus.

History

Ethadione was first synthesized in the 1950s and was used as an anticonvulsant for several decades. However, it was withdrawn from the market due to its teratogenic effects, which can cause birth defects in the fetus.

Mechanism of Action

Ethadione works by inhibiting the spread of seizure activity in the brain. It does this by reducing the abnormal electrical activity in the brain.

Side Effects

The side effects of ethadione include dizziness, nausea, and vomiting. In rare cases, it can cause skin rash, jaundice, and anemia. The most serious side effect is its teratogenic effect, which can cause birth defects in the fetus.

Contraindications

Ethadione is contraindicated in pregnant women due to its teratogenic effects. It is also contraindicated in patients with liver disease or blood disorders.

Interactions

Ethadione can interact with other anticonvulsants, increasing their effects and potentially causing toxicity. It can also interact with alcohol, increasing its effects and potentially causing drowsiness and impaired coordination.

Withdrawal

Ethadione was withdrawn from the market due to its teratogenic effects. However, it is still available in some countries for use in patients who cannot tolerate other anticonvulsants.

See Also

• Anticonvulsant
• Seizure
• Teratogen

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