Artesunate/mefloquine

Artesunate/mefloquine is a combination of two antimalarial medications, artesunate and mefloquine. It is used to treat malaria, a disease caused by parasites that enter the body through the bite of a mosquito.

Mechanism of Action

Artesunate works by producing free radicals within the malarial parasite, which kills it. Mefloquine, on the other hand, damages the parasite's DNA and interferes with its ability to reproduce.

Indications

Artesunate/mefloquine is indicated for the treatment of acute uncomplicated malaria infections due to Plasmodium falciparum in adults and children.

Contraindications

Artesunate/mefloquine is contraindicated in patients with known hypersensitivity to artesunate, mefloquine, or any component of the formulation. It is also contraindicated in patients with a history of psychiatric disorders or seizures.

Side Effects

Common side effects of artesunate/mefloquine include nausea, vomiting, diarrhea, abdominal pain, and dizziness. Serious side effects may include QT prolongation, severe allergic reactions, and neuropsychiatric effects.

Drug Interactions

Artesunate/mefloquine may interact with other medications, including antiretroviral drugs, antiepileptic drugs, and other antimalarial medications.

Dosage and Administration

The dosage of artesunate/mefloquine depends on the patient's weight. It is usually taken once a day for three days.

Precautions

Patients should be monitored for signs of hypersensitivity reactions and neuropsychiatric effects. Electrocardiogram (ECG) monitoring should be considered in patients with risk factors for QT prolongation.

Pregnancy and Lactation

Artesunate/mefloquine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether artesunate/mefloquine is excreted in human milk.

See Also

• Malaria
• Antimalarial medication
• Artesunate
• Mefloquine

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