Tulobuterol

Tulobuterol is a long-acting beta2 adrenergic receptor agonist (LABA) used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed under the brand names Tulobuterol patch, Tulobuterol tape, and Tulobuterol sheet in Japan and South Korea.

Etymology

The name "Tulobuterol" is derived from its chemical structure, which includes a tert-butyl group and a phenol group. The "Tulo-" prefix is derived from "tert-butyl", and the "-buterol" suffix is common among other beta2 adrenergic receptor agonists, such as salbutamol and terbutaline.

Pharmacology

Tulobuterol acts as a bronchodilator, relaxing the smooth muscle in the airways to improve breathing. It is a selective beta2 adrenergic receptor agonist, meaning it primarily acts on the beta2 adrenergic receptors in the lungs. This selectivity helps to minimize side effects associated with stimulation of beta1 adrenergic receptors, such as increased heart rate.

Clinical Use

Tulobuterol is used in the treatment of asthma and COPD. It is typically administered via a transdermal patch, which allows for continuous delivery of the drug over a 24-hour period. This method of administration provides consistent bronchodilation and is convenient for patients, as it only requires once-daily application.

Side Effects

Common side effects of Tulobuterol include palpitations, tremor, and headache. Less common side effects may include hypokalemia, hyperglycemia, and muscle cramps. As with all LABAs, there is a risk of paradoxical bronchospasm, where the medication causes the airways to narrow instead of widen.

See Also

• Beta2 adrenergic receptor agonist
• Asthma
• Chronic obstructive pulmonary disease

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