Nanoimpellers
Nanoimpellers are an experimental technology developed to eliminate some of the harmful effects of chemotherapy by facilitating treatment of only specific areas of the body. Nanoimpellers are nanoscale, light-activated containers filled with cancer-fighting drugs that only release their contents when hit by a specific type of laser.<ref name="Zheng2010">,
Molecular machines drive smart drug delivery, Nanomedicine, Vol. 5(Issue: 9), pp. 1309–1312, DOI: 10.2217/nnm.10.111, PMID: 21128714,</ref>
Nanoimpellers for cancer drug delivery were first demonstrated in 2008.<ref>,
Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells, Small, Vol. 4(Issue: 4), pp. 421–426, DOI: 10.1002/smll.200700903, PMID: 18383576, PMC: 2712492,</ref><ref>
,
Nanomachine Kills Cancer Cells With Exposure To Light Full text, , Inventorspot, 25 April 2008,
</ref> Initial work used ultraviolet light, however the low penetration in tissue and potential for toxicity mean this is not well suited for delivery in patients.<ref name="Zheng2010" /> Later work has shifted to using near infrared light and two photon excitation (TPE) to trigger release.<ref>,
Photochromic Materials: Preparation, Properties and Applications. online version, John Wiley & Sons, ISBN 9783527683703,</ref><ref>, Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers, Angewandte Chemie International Edition, Vol. 52(Issue: 51), pp. 13813–13817, DOI: 10.1002/anie.201308647, PMID: 24214916, PMC: 3940420,</ref>
See also
References
External links
,
A Little Hope for Cancer Treatment Full text, Wired, 6 May 2008,
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