Flurpiridaz (18F)
A radiopharmaceutical used in PET imaging of the heart
Flurpiridaz (18F) is a radiopharmaceutical used in positron emission tomography (PET) imaging, specifically for the assessment of myocardial perfusion. It is a fluorine-18 labeled compound that binds to mitochondrial complex I, allowing for detailed imaging of the heart's blood flow.
Chemical Properties
Flurpiridaz (18F) is a fluorine-18 labeled pyridazinone derivative. The presence of the radioactive isotope fluorine-18 allows it to be used in PET imaging due to its positron-emitting properties. The chemical structure of Flurpiridaz (18F) facilitates its binding to mitochondrial complex I, which is abundant in cardiac tissue.
Mechanism of Action
Flurpiridaz (18F) works by targeting mitochondrial complex I in the heart muscle cells. This complex is a crucial part of the electron transport chain, which is involved in cellular respiration. By binding to this complex, Flurpiridaz (18F) allows for the visualization of myocardial perfusion, providing insights into the blood flow and function of the heart muscle.
Clinical Applications
Flurpiridaz (18F) is primarily used in the evaluation of myocardial perfusion. It is particularly useful in patients with suspected or known coronary artery disease (CAD). The high resolution and quantitative capabilities of PET imaging with Flurpiridaz (18F) make it a valuable tool in assessing the severity and extent of CAD, as well as in evaluating the effectiveness of therapeutic interventions.
Advantages over Other Imaging Agents
Compared to traditional SPECT imaging agents, Flurpiridaz (18F) offers several advantages:
- Higher Resolution: PET imaging provides superior spatial resolution compared to SPECT, allowing for more detailed images of the heart.
- Quantitative Analysis: PET allows for quantitative assessment of myocardial blood flow, which can be critical in evaluating the severity of CAD.
- Shorter Half-life: The half-life of fluorine-18 is approximately 110 minutes, which is shorter than some other isotopes, reducing radiation exposure to the patient.
Development and Approval
Flurpiridaz (18F) is currently under investigation in clinical trials to further establish its safety and efficacy. It has shown promise in early studies, demonstrating superior image quality and diagnostic accuracy compared to existing imaging agents.
Related pages
Ad. Transform your life with W8MD's Budget GLP-1 injections from $75
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Weight loss injections in NYC (generic and brand names):
- Zepbound / Mounjaro, Wegovy / Ozempic, Saxenda
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $75 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointmentsNYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
