Motretinide

Motretinide is a synthetic derivative of vitamin A, used in the treatment of skin diseases. It is a member of the retinoid family of compounds, which are known for their ability to regulate cell growth and differentiation. Motretinide is primarily used in the treatment of acne and psoriasis, but it has also been investigated for its potential use in the prevention of skin cancer.

History

Motretinide was first synthesized in the 1980s by the pharmaceutical company Roche. It was initially developed as a treatment for acne, but its potential use in the treatment of other skin diseases was soon recognized.

Pharmacology

Motretinide works by binding to and activating retinoic acid receptors (RARs) in the skin. This leads to an increase in the turnover of skin cells, which can help to clear up acne and reduce the symptoms of psoriasis. In addition, motretinide has been shown to inhibit the growth of skin cancer cells in laboratory studies.

Side Effects

The most common side effects of motretinide are skin irritation and increased sensitivity to sunlight. Less common side effects include dry skin, itching, and redness. In rare cases, motretinide can cause severe skin reactions, including erythema multiforme and Stevens-Johnson syndrome.

See Also

• Retinoid
• Acne
• Psoriasis
• Skin cancer

References

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