Benign hereditary chorea

Benign hereditary chorea (BHC)
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Synonyms	Benign familial chorea
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Field	N/A
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Benign hereditary chorea (BHC), also known as benign familial chorea, is a rare autosomal dominant neurogenetic syndrome. It typically presents in childhood with isolated chorea, with or without dull normal intelligence. Unlike other neurogenetic causes of chorea such as Huntington's disease, BHC is not progressive, and not associated with cognitive decline or psychiatric problems in the vast majority of cases.<ref name="Kleiner-Fisman-2003">,

 Benign hereditary chorea: clinical, genetic, and pathological findings., 
 Annals of Neurology, 
 
 Vol. 54(Issue: 2),
 pp. 244–7,
 DOI: 10.1002/ana.10637,
 PMID: 12891678,</ref>

BHC is caused by a single-nucleotide insertion mutation in TITF1, which encodes thyroid transcription factor 1 (TTF-1). This gene is also known as NK2 homeobox 1 (NKX2-1)<ref name="Kleiner-Fisman-2003" />

In some cases, additional developmental abnormalities of lung and thyroid tissue are found in BHC, leading to the suggested alternative name brain-lung-thyroid syndrome.<ref>,

 Benign Hereditary Chorea: An Update., 
 Tremor and Other Hyperkinetic Movements, 
 
 Vol. 5,
 pp. 314,
 DOI: 10.7916/D8RJ4HM5,
 PMID: 26196025,
 PMC: 4502401,</ref>

See also

• Chorea
• Huntington's disease

External links

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