Platinum-based antineoplastic

Platinum-based antineoplastic is a type of chemotherapy drug that contains platinum, a heavy metal. These drugs are used to treat various types of cancer, including testicular cancer, ovarian cancer, bladder cancer, head and neck cancer, and lung cancer.

Mechanism of Action

Platinum-based antineoplastic drugs work by interfering with the DNA in cancer cells, preventing them from dividing and growing. They do this by forming covalent bonds with the DNA, which distorts its structure and prevents it from being read correctly by the cell's machinery. This causes the cell to die.

Types of Platinum-based Antineoplastic Drugs

There are several types of platinum-based antineoplastic drugs, including:

• Cisplatin
• Carboplatin
• Oxaliplatin
• Liposomal cisplatin

Each of these drugs has a slightly different chemical structure, which affects how they interact with DNA and how they are processed by the body.

Side Effects

Like all chemotherapy drugs, platinum-based antineoplastics can have side effects. These can include:

• Nausea and vomiting
• Hair loss
• Fatigue
• Neuropathy
• Kidney damage
• Hearing loss

The severity of these side effects can vary depending on the specific drug used, the dose, and the individual patient's health.

See Also

• Chemotherapy
• Cancer
• DNA
• Side effect

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