Chlorosibutramine

Chlorosibutramine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that was previously used as an anti-obesity medication. It was withdrawn from the market due to concerns about its cardiovascular side effects.

Pharmacology

Chlorosibutramine acts by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters that are involved in the regulation of mood and appetite. By increasing the levels of these neurotransmitters in the brain, chlorosibutramine can help to reduce appetite and promote weight loss.

Medical uses

Chlorosibutramine was primarily used as a treatment for obesity. It was typically prescribed for individuals who had not been able to lose weight through diet and exercise alone. However, due to concerns about its safety, it is no longer available for this use.

Side effects

The most common side effects of chlorosibutramine include dry mouth, constipation, and insomnia. However, it can also cause more serious side effects, such as increased heart rate and blood pressure. In some cases, these cardiovascular effects can lead to serious complications, such as heart attack or stroke.

History

Chlorosibutramine was first approved for use as an anti-obesity medication in the 1980s. However, it was withdrawn from the market in the 1990s due to concerns about its cardiovascular side effects. Despite this, it is still occasionally used off-label for weight loss.

See also

• Serotonin-norepinephrine reuptake inhibitor
• Anti-obesity medication

References

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