AS-19 (drug)

A selective 5-HT₇ receptor agonist

AS-19 (drug)
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

AS-19 is a chemical compound that acts as a selective agonist for the [[5-HT₇ receptor]], a subtype of the serotonin receptor. It is used primarily in scientific research to study the role of the 5-HT₇ receptor in various physiological and neurological processes.

Pharmacology

AS-19 is known for its high selectivity towards the 5-HT₇ receptor, which is a G protein-coupled receptor (GPCR) involved in the modulation of neurotransmitter release, circadian rhythm, and mood regulation. The activation of 5-HT₇ receptors by AS-19 has been shown to influence neurotransmission and neuroplasticity, making it a valuable tool in neuroscience research.

Mechanism of Action

AS-19 binds to the 5-HT₇ receptor and mimics the action of the endogenous ligand, serotonin. This binding leads to the activation of intracellular signaling pathways, including the adenylate cyclase pathway, which increases the levels of cyclic adenosine monophosphate (cAMP) within the cell. The increase in cAMP can lead to various downstream effects, such as changes in gene expression and synaptic plasticity.

Research Applications

AS-19 is utilized in research to explore the physiological and behavioral effects of 5-HT₇ receptor activation. Studies have investigated its role in:

• Circadian rhythm regulation
• Mood disorders such as depression and anxiety
• Cognitive function and memory
• Pain perception and nociception

Potential Therapeutic Uses

While AS-19 itself is not used therapeutically, research on 5-HT₇ receptor agonists like AS-19 may lead to the development of new treatments for conditions such as depression, schizophrenia, and migraine.

Safety and Toxicology

As a research chemical, AS-19 is not intended for human consumption. Studies involving AS-19 are conducted under controlled laboratory conditions to ensure safety and to understand its pharmacokinetic and pharmacodynamic properties.

Related pages

• Serotonin receptor
• 5-HT receptor
• Neurotransmitter
• G protein-coupled receptor