Oxilorphan

Oxilorphan is an opioid antagonist that was developed in the 1970s. It is related to naloxone and is similar in effects, but has a longer duration of action. Oxilorphan is used in the treatment of drug addiction and has been researched for use in the treatment of pain.

Chemistry

Oxilorphan is a derivative of morphinan, which is a type of opioid. It is structurally similar to other opioid antagonists such as naloxone and naltrexone. The chemical name for oxilorphan is 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-[(phenylthio)methyl]morphinan.

Pharmacology

Oxilorphan acts by binding to the mu opioid receptor, where it has antagonist effects. This means it blocks the effects of other opioids, which can be useful in treating opioid addiction. It can also be used to reverse the effects of opioids in cases of overdose.

Clinical uses

Oxilorphan has been used in the treatment of opioid addiction. It can help to reduce cravings and withdrawal symptoms in people who are dependent on opioids. It has also been researched for use in the treatment of pain, although it is not commonly used for this purpose.

Side effects

Like other opioid antagonists, oxilorphan can cause withdrawal symptoms in people who are dependent on opioids. These can include restlessness, irritability, and physical discomfort. Other side effects can include nausea, vomiting, and increased heart rate.

See also

• Opioid antagonist
• Naloxone
• Naltrexone

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