4-PPBP

Chemical compound

4-PPBP is a chemical compound that acts as a selective antagonist of the sigma-1 receptor. It is used in scientific research to study the role of sigma receptors in various biological processes.

Chemical Structure

4-PPBP, also known as 4-phenyl-1-(4-phenylbutyl)piperidine, is a piperidine derivative. Its chemical structure consists of a piperidine ring substituted with a phenyl group and a phenylbutyl group.

Pharmacology

4-PPBP is primarily known for its action as a sigma-1 receptor antagonist. The sigma-1 receptor is a chaperone protein involved in modulating ion channels, neurotransmitter release, and cell survival. By blocking this receptor, 4-PPBP can influence various physiological and pathological processes.

Research Applications

In research, 4-PPBP is used to investigate the function of sigma-1 receptors in the central nervous system and other tissues. It has been studied in the context of neuroprotection, pain management, and cancer.

Sigma Receptors

Sigma receptors are a class of proteins that bind to psychotropic drugs and are involved in the regulation of several cellular functions. There are two main types: sigma-1 receptor and sigma-2 receptor. 4-PPBP specifically targets the sigma-1 receptor.

Gallery

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  3D model of 4-PPBP

Related Pages

• Sigma receptor
• Piperidine
• Neuropharmacology