Transplatin

Chemical compound

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Transplatin, or trans-dichlorodiammineplatinum(II), is a chemical compound with the formula trans-[PtCl₂(NH₃)₂]. It is an isomer of the more well-known cisplatin, which is used as a chemotherapy drug. Unlike cisplatin, transplatin is not effective as an anticancer agent.

Structure and properties

Transplatin is a coordination complex of platinum with two chloride ions and two ammonia molecules. The compound is characterized by its trans configuration, meaning that the two chloride ions are opposite each other in the molecular structure. This configuration is in contrast to the cis configuration found in cisplatin, where the chloride ions are adjacent.

The trans configuration of transplatin affects its chemical reactivity and biological activity. The compound is less able to form cross-links with DNA, which is a key mechanism by which cisplatin exerts its anticancer effects. As a result, transplatin does not have the same therapeutic properties as cisplatin.

Synthesis

Transplatin can be synthesized by the reaction of potassium tetrachloroplatinate(II) with ammonia in the presence of a chloride source. The reaction typically involves the formation of an intermediate complex, which rearranges to form the trans isomer. The synthesis of transplatin is often carried out in an aqueous solution, and the product can be isolated by crystallization.

Applications

While transplatin itself is not used as a drug, it serves as a useful compound in the study of platinum-based chemotherapy agents. Researchers have investigated various derivatives of transplatin in an effort to develop new anticancer drugs with improved properties. Some of these derivatives have shown promise in preclinical studies.

Related compounds

• Cisplatin
• Carboplatin
• Oxaliplatin

References

• ,

 Platinum compounds: a new class of potent antitumour agents, 
 Nature, 
 1969,
 Vol. 222(Issue: 5191),
 pp. 385–386,
 DOI: 10.1038/222385a0,

• B. K.,

 Metal Complexes in Cancer Chemotherapy, 
  
 VCH, 
 1993, 
  
  
 ISBN 978-3-527-28302-4,

Related pages

• Chemotherapy
• Coordination chemistry
• Platinum