Traxoprodil

Traxoprodil

Chemical structure of Traxoprodil

Traxoprodil is a pharmaceutical compound that acts as a selective NMDA receptor antagonist. It is primarily investigated for its potential therapeutic effects in treating neuropathic pain and other neurological disorders.

Mechanism of Action

Traxoprodil functions by selectively inhibiting the NR2B subunit of the NMDA receptor. This receptor is a type of glutamate receptor that plays a crucial role in synaptic plasticity and memory function. By blocking the NR2B subunit, Traxoprodil reduces the excitotoxicity associated with excessive glutamate activity, which is implicated in various neurological conditions.

Clinical Research

Research into Traxoprodil has focused on its potential to alleviate symptoms of neuropathic pain, a chronic pain condition resulting from nerve damage. Studies have also explored its use in treating major depressive disorder and stroke. However, clinical trials have yielded mixed results, and further research is needed to fully understand its efficacy and safety profile.

Side Effects

Common side effects of Traxoprodil include dizziness, nausea, and headache. As with other NMDA receptor antagonists, there is a risk of neurotoxicity and cognitive impairment with prolonged use. Monitoring and dosage adjustments are necessary to minimize adverse effects.

Related Compounds

Traxoprodil is part of a class of drugs known as NR2B-selective NMDA receptor antagonists. Other compounds in this class include ifenprodil and eliprodil, which have similar mechanisms of action and therapeutic potential.

Related Pages

• NMDA receptor antagonist
• Neuropathic pain
• Glutamate receptor