P2RY11

P2RY11 is a gene that encodes the P2Y11 receptor, a member of the G protein-coupled receptor family. This receptor is predominantly expressed in immune cells, where it plays a crucial role in immune response modulation.

Function

The P2RY11 gene encodes a G protein-coupled receptor that responds to extracellular adenosine diphosphate (ADP) and adenosine triphosphate (ATP). The receptor is coupled to both the Gs and Gq G proteins, which leads to the activation of both adenylyl cyclase and phospholipase C pathways. This dual coupling allows the receptor to mediate a wide range of physiological responses, including platelet aggregation, neutrophil chemotaxis, and T cell activation.

Clinical Significance

Mutations in the P2RY11 gene have been associated with a susceptibility to autoimmune diseases, including Graves' disease and systemic lupus erythematosus. The receptor's role in immune response modulation makes it a potential target for the development of new immunotherapy treatments.

File:P2Y11 Receptor.png

The P2Y11 receptor, encoded by the P2RY11 gene.

See Also

• P2Y receptor
• G protein-coupled receptor
• Adenosine diphosphate
• Adenosine triphosphate
• Graves' disease
• Systemic lupus erythematosus

References

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