H1299

H1299 is a human lung carcinoma cell line that is commonly used in scientific research. This cell line is particularly useful for studying the function of the p53 gene, as it lacks this gene. The H1299 cell line is also used in studies of lung cancer, gene expression, and drug resistance.

History

The H1299 cell line was established in 1980 from the lymph node metastasis of a 43-year-old Caucasian male with primary lung carcinoma. The cell line was derived by A.F. Gazdar, J.D. Minna, and colleagues at the National Cancer Institute (NCI) and the University of Texas Southwestern Medical Center.

Characteristics

H1299 cells are epithelial in morphology and grow in adherent culture. They are negative for the p53 gene, making them a useful model for studying the function of this gene. The cells are also resistant to many common chemotherapeutic drugs, making them a valuable tool for studying drug resistance in lung cancer.

Applications

H1299 cells are widely used in scientific research. They are particularly useful for studying the function of the p53 gene, as they lack this gene. The cells are also used in studies of lung cancer, gene expression, and drug resistance.

References

1. Gazdar AF, et al. Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. Int. J. Cancer 35: 69-77, 1985.
2. Minna JD, et al. Molecular biology of lung cancer: Clinical implications. Clin. Chest Med. 13: 415-429, 1992.

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