Dim

Dimethyl Sulfoxide (DMSO)

Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH₃)₂SO. It is a colorless liquid that is an important polar aprotic solvent. DMSO is notable for its ability to penetrate biological membranes, which makes it a valuable tool in medical and pharmaceutical applications.

Chemical Properties

DMSO is a highly polar organic liquid, and it is miscible with a wide range of organic solvents as well as water. Its chemical structure consists of a sulfur atom bonded to two methyl groups and an oxygen atom, giving it the formula (CH₃)₂SO. The sulfur-oxygen bond is a sulfoxide functional group, which is responsible for many of its unique properties.

Medical Uses

DMSO is used in medicine primarily for its ability to penetrate the skin and other biological membranes. It is used as a topical analgesic, a vehicle for topical application of pharmaceuticals, and as an anti-inflammatory agent. DMSO is also used in cryopreservation, where it acts as a cryoprotectant to protect cells from damage during the freezing process.

Pain Relief

DMSO is applied topically to reduce pain and inflammation in conditions such as arthritis and muscle injuries. It is believed to work by reducing the transmission of pain signals and by reducing inflammation at the site of application.

Cryopreservation

In cryopreservation, DMSO is used to protect cells and tissues from ice crystal formation during freezing. It is commonly used in the preservation of stem cells, sperm, and other biological samples.

Safety and Side Effects

While DMSO is generally considered safe when used appropriately, it can cause side effects such as skin irritation, a garlic-like taste in the mouth, and a garlic-like odor on the breath and skin. It is important to use pharmaceutical-grade DMSO and to follow appropriate guidelines for its use.

Research and Controversies

DMSO has been the subject of extensive research, and while it has many approved uses, some of its purported benefits remain controversial. Research continues into its potential applications in treating conditions such as interstitial cystitis, scleroderma, and other inflammatory diseases.

Conclusion

Dimethyl sulfoxide is a versatile compound with a wide range of applications in medicine and industry. Its ability to penetrate biological membranes and its role as a solvent make it a valuable tool in both research and clinical settings.

References

• ,

 Dimethyl sulfoxide (DMSO) after twenty years, 
 Annals of the New York Academy of Sciences, 
 1983,
 Vol. 411,
 pp. 1–403,
 DOI: 10.1111/j.1749-6632.1983.tb47301.x,

• David A.,

 The DMSO Handbook for Doctors, 
  
 Penguin Books, 
 1993, 
  
  
 ISBN 978-0895295488,