11-Hydroxycannabinol

11-Hydroxycannabinol

File:11-OH-CBN structure.png

Chemical structure of 11-Hydroxycannabinol

11-Hydroxycannabinol (11-OH-CBN) is a cannabinoid metabolite that is formed in the body after the consumption of cannabis. It is a hydroxylated form of cannabinol (CBN), which itself is a degradation product of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure

11-Hydroxycannabinol is characterized by the addition of a hydroxyl group (-OH) at the 11th carbon position of the CBN molecule. This modification alters the chemical properties and biological activity of the compound compared to its parent molecule, CBN.

Pharmacology

11-Hydroxycannabinol is known to interact with the endocannabinoid system, specifically binding to cannabinoid receptors such as CB1 and CB2. These interactions can influence various physiological processes, including mood, appetite, and pain perception.

Metabolism

In the human body, 11-Hydroxycannabinol is produced primarily in the liver through the action of cytochrome P450 enzymes on CBN. This metabolic pathway is similar to the conversion of THC to 11-Hydroxy-THC, another active metabolite.

Biological Effects

The biological effects of 11-Hydroxycannabinol are not as well-studied as those of THC or CBN. However, it is believed to have a lower psychoactive potency compared to THC. Its effects on the body may include mild sedation and analgesia, but further research is needed to fully understand its pharmacological profile.

Related Compounds

• Cannabinol (CBN)
• Tetrahydrocannabinol (THC)
• 11-Hydroxy-THC
• Cannabidiol (CBD)

Related Pages

• Cannabinoid
• Endocannabinoid system
• Cannabis