GRIN disorder
- GRIN disorders (also GRIN-related disorders) are a group of neurodevelopmental disorders that result from mutations in genes coding for subunits of an N-methyl-D-aspartate (NMDA) receptor, which leads to dysfunction of glutamate signaling. GRIN disorders are universally characterized by a varying degree of developmental delay and intellectual disability, as well as epileptic seizures. Other clinical features vary depending on the affected and may include muscular hypotonia, spasticity, and movement disorders. GRIN disorders are confirmed with genetic testing and managed symptomatically since there is currently no cure for the disorder. [[Category:Uncategorized
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