Immunodeficiency 26: Difference between revisions
From WikiMD's Wellness Encyclopedia
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Immunodeficiency 26 | |||
| image = [[File:Autorecessive.svg|200px]] | |||
| caption = Autosomal recessive pattern | |||
| field = [[Immunology]] | |||
| symptoms = Recurrent [[infections]], [[autoimmune disorders]] | |||
| complications = Increased risk of [[cancer]] | |||
| onset = Childhood | |||
| duration = Lifelong | |||
| causes = Genetic mutations in the [[SP110]] gene | |||
| risks = Family history of the condition | |||
| diagnosis = [[Genetic testing]], [[blood tests]] | |||
| differential = Other forms of [[immunodeficiency]] | |||
| treatment = [[Immunoglobulin therapy]], [[antibiotics]], [[hematopoietic stem cell transplantation]] | |||
| prognosis = Variable, depending on severity and treatment | |||
| frequency = Rare | |||
}} | |||
'''Immunodeficiency''' is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either [[primary immunodeficiency|primary]] or [[secondary immunodeficiency|secondary]]. | '''Immunodeficiency''' is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either [[primary immunodeficiency|primary]] or [[secondary immunodeficiency|secondary]]. | ||
== Types of Immunodeficiency == | == Types of Immunodeficiency == | ||
=== Primary Immunodeficiency === | === Primary Immunodeficiency === | ||
Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an [[autosomal recessive]] pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including [[B cells]], [[T cells]], and [[complement system|complement proteins]]. | Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an [[autosomal recessive]] pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including [[B cells]], [[T cells]], and [[complement system|complement proteins]]. | ||
=== Secondary Immunodeficiency === | === Secondary Immunodeficiency === | ||
Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include [[HIV/AIDS]], [[malnutrition]], and certain medical treatments such as [[chemotherapy]] and [[immunosuppressive drugs]]. | Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include [[HIV/AIDS]], [[malnutrition]], and certain medical treatments such as [[chemotherapy]] and [[immunosuppressive drugs]]. | ||
== Symptoms == | == Symptoms == | ||
Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include: | Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include: | ||
| Line 15: | Line 29: | ||
* Persistent [[diarrhea]] | * Persistent [[diarrhea]] | ||
* Skin infections | * Skin infections | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include: | Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include: | ||
| Line 22: | Line 35: | ||
* Specific antibody response tests | * Specific antibody response tests | ||
* Genetic testing for primary immunodeficiencies | * Genetic testing for primary immunodeficiencies | ||
== Treatment == | == Treatment == | ||
Treatment depends on the type and severity of the immunodeficiency. Options may include: | Treatment depends on the type and severity of the immunodeficiency. Options may include: | ||
| Line 29: | Line 41: | ||
* [[Bone marrow transplant]] for severe cases | * [[Bone marrow transplant]] for severe cases | ||
* Lifestyle modifications to reduce infection risk | * Lifestyle modifications to reduce infection risk | ||
== See also == | |||
== | |||
* [[Immune system]] | * [[Immune system]] | ||
* [[Autoimmune disease]] | * [[Autoimmune disease]] | ||
* [[HIV/AIDS]] | * [[HIV/AIDS]] | ||
* [[Vaccination]] | * [[Vaccination]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 21:27, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Immunodeficiency 26 | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Recurrent infections, autoimmune disorders |
| Complications | Increased risk of cancer |
| Onset | Childhood |
| Duration | Lifelong |
| Types | N/A |
| Causes | Genetic mutations in the SP110 gene |
| Risks | Family history of the condition |
| Diagnosis | Genetic testing, blood tests |
| Differential diagnosis | Other forms of immunodeficiency |
| Prevention | N/A |
| Treatment | Immunoglobulin therapy, antibiotics, hematopoietic stem cell transplantation |
| Medication | N/A |
| Prognosis | Variable, depending on severity and treatment |
| Frequency | Rare |
| Deaths | N/A |
Immunodeficiency is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either primary or secondary.
Types of Immunodeficiency[edit]
Primary Immunodeficiency[edit]
Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an autosomal recessive pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including B cells, T cells, and complement proteins.
Secondary Immunodeficiency[edit]
Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include HIV/AIDS, malnutrition, and certain medical treatments such as chemotherapy and immunosuppressive drugs.
Symptoms[edit]
Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include:
Diagnosis[edit]
Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include:
- Complete blood count (CBC)
- Quantitative immunoglobulins
- Specific antibody response tests
- Genetic testing for primary immunodeficiencies
Treatment[edit]
Treatment depends on the type and severity of the immunodeficiency. Options may include:
- Antibiotics to treat infections
- Immunoglobulin therapy
- Bone marrow transplant for severe cases
- Lifestyle modifications to reduce infection risk
