Ectopia lentis: Difference between revisions
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{{Infobox medical condition | |||
| name = Ectopia lentis | |||
| image = [[File:Ectopia_Lentis_in_Marfan_syndrome.jpg]] | |||
| caption = Ectopia lentis in [[Marfan syndrome]] | |||
| field = [[Ophthalmology]] | |||
| synonyms = Lens dislocation, lens subluxation | |||
| symptoms = Blurred vision, double vision, visual distortion | |||
| complications = [[Retinal detachment]], [[glaucoma]], [[cataract]] | |||
| onset = Can be congenital or acquired | |||
| duration = Chronic | |||
| causes = Genetic disorders, trauma, [[homocystinuria]], [[Marfan syndrome]], [[Ehlers-Danlos syndrome]] | |||
| risks = Family history, connective tissue disorders | |||
| diagnosis = [[Slit lamp]] examination, [[ultrasound biomicroscopy]], [[genetic testing]] | |||
| differential = [[Keratoconus]], [[cataract]], [[retinal detachment]] | |||
| treatment = Corrective lenses, [[surgery]] | |||
| medication = None specific, but may include [[eye drops]] for associated conditions | |||
| prognosis = Variable, depending on underlying cause and treatment | |||
| frequency = Rare | |||
| deaths = Not directly fatal | |||
}} | |||
'''Ectopia lentis''' is a rare, hereditary disorder that affects the eyes, specifically the lens. The lens is a clear structure in the eye that helps to focus light on the retina. In people with ectopia lentis, the lens is displaced or malpositioned. This displacement can occur in any direction and can vary in severity. Ectopia lentis can be an isolated condition or it can be associated with other systemic disorders such as [[Marfan syndrome]] or [[Homocystinuria]]. | '''Ectopia lentis''' is a rare, hereditary disorder that affects the eyes, specifically the lens. The lens is a clear structure in the eye that helps to focus light on the retina. In people with ectopia lentis, the lens is displaced or malpositioned. This displacement can occur in any direction and can vary in severity. Ectopia lentis can be an isolated condition or it can be associated with other systemic disorders such as [[Marfan syndrome]] or [[Homocystinuria]]. | ||
== Causes == | == Causes == | ||
Ectopia lentis is usually caused by a mutation in the [[FBN1]] gene. This gene provides instructions for making a protein called fibrillin-1. Fibrillin-1 is an important component of the connective tissue that provides strength and flexibility to many structures in the body. When the FBN1 gene is mutated, it can lead to the production of abnormal fibrillin-1 protein, which can cause the lens to become dislocated. | Ectopia lentis is usually caused by a mutation in the [[FBN1]] gene. This gene provides instructions for making a protein called fibrillin-1. Fibrillin-1 is an important component of the connective tissue that provides strength and flexibility to many structures in the body. When the FBN1 gene is mutated, it can lead to the production of abnormal fibrillin-1 protein, which can cause the lens to become dislocated. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of ectopia lentis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience severe vision problems. Common symptoms include: | The symptoms of ectopia lentis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience severe vision problems. Common symptoms include: | ||
* [[Nearsightedness]] (myopia) | * [[Nearsightedness]] (myopia) | ||
* [[Farsightedness]] (hyperopia) | * [[Farsightedness]] (hyperopia) | ||
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* [[Double vision]] | * [[Double vision]] | ||
* [[Glaucoma]] | * [[Glaucoma]] | ||
== Diagnosis == | == Diagnosis == | ||
Ectopia lentis is typically diagnosed through a comprehensive eye examination. This may include a [[Slit lamp examination]], which allows the doctor to examine the structures at the front of the eye under magnification. Genetic testing may also be performed to confirm the diagnosis and identify any associated systemic disorders. | Ectopia lentis is typically diagnosed through a comprehensive eye examination. This may include a [[Slit lamp examination]], which allows the doctor to examine the structures at the front of the eye under magnification. Genetic testing may also be performed to confirm the diagnosis and identify any associated systemic disorders. | ||
== Treatment == | == Treatment == | ||
Treatment for ectopia lentis depends on the severity of the condition and the presence of any associated disorders. In mild cases, corrective lenses may be sufficient to improve vision. In more severe cases, surgery may be required to reposition or replace the dislocated lens. | Treatment for ectopia lentis depends on the severity of the condition and the presence of any associated disorders. In mild cases, corrective lenses may be sufficient to improve vision. In more severe cases, surgery may be required to reposition or replace the dislocated lens. | ||
== Ectopia_lentis gallery == | |||
<gallery> | |||
File:Luxating_lens_-_anterior.JPG|Luxating lens - anterior | |||
File:Feline_lens_luxation_2.JPG|Feline lens luxation | |||
</gallery> | |||
== See also == | == See also == | ||
* [[Marfan syndrome]] | * [[Marfan syndrome]] | ||
* [[Homocystinuria]] | * [[Homocystinuria]] | ||
* [[FBN1]] | * [[FBN1]] | ||
* [[Slit lamp examination]] | * [[Slit lamp examination]] | ||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
[[Category:Eye disorders]] | [[Category:Eye disorders]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 16:05, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Ectopia lentis | |
|---|---|
| |
| Synonyms | Lens dislocation, lens subluxation |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Blurred vision, double vision, visual distortion |
| Complications | Retinal detachment, glaucoma, cataract |
| Onset | Can be congenital or acquired |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic disorders, trauma, homocystinuria, Marfan syndrome, Ehlers-Danlos syndrome |
| Risks | Family history, connective tissue disorders |
| Diagnosis | Slit lamp examination, ultrasound biomicroscopy, genetic testing |
| Differential diagnosis | Keratoconus, cataract, retinal detachment |
| Prevention | N/A |
| Treatment | Corrective lenses, surgery |
| Medication | None specific, but may include eye drops for associated conditions |
| Prognosis | Variable, depending on underlying cause and treatment |
| Frequency | Rare |
| Deaths | Not directly fatal |
Ectopia lentis is a rare, hereditary disorder that affects the eyes, specifically the lens. The lens is a clear structure in the eye that helps to focus light on the retina. In people with ectopia lentis, the lens is displaced or malpositioned. This displacement can occur in any direction and can vary in severity. Ectopia lentis can be an isolated condition or it can be associated with other systemic disorders such as Marfan syndrome or Homocystinuria.
Causes[edit]
Ectopia lentis is usually caused by a mutation in the FBN1 gene. This gene provides instructions for making a protein called fibrillin-1. Fibrillin-1 is an important component of the connective tissue that provides strength and flexibility to many structures in the body. When the FBN1 gene is mutated, it can lead to the production of abnormal fibrillin-1 protein, which can cause the lens to become dislocated.
Symptoms[edit]
The symptoms of ectopia lentis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience severe vision problems. Common symptoms include:
- Nearsightedness (myopia)
- Farsightedness (hyperopia)
- Astigmatism
- Blurry vision
- Double vision
- Glaucoma
Diagnosis[edit]
Ectopia lentis is typically diagnosed through a comprehensive eye examination. This may include a Slit lamp examination, which allows the doctor to examine the structures at the front of the eye under magnification. Genetic testing may also be performed to confirm the diagnosis and identify any associated systemic disorders.
Treatment[edit]
Treatment for ectopia lentis depends on the severity of the condition and the presence of any associated disorders. In mild cases, corrective lenses may be sufficient to improve vision. In more severe cases, surgery may be required to reposition or replace the dislocated lens.
Ectopia_lentis gallery[edit]
-
Luxating lens - anterior -
Feline lens luxation
See also[edit]
References[edit]
<references group="" responsive="1"></references>
