Desmoplastic melanoma: Difference between revisions
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{{Infobox medical condition | |||
| name = Desmoplastic melanoma | |||
| image = [[File:Skin_Tumors-045.jpg|alt=Desmoplastic melanoma]] | |||
| caption = Desmoplastic melanoma on the skin | |||
| field = [[Dermatology]], [[Oncology]] | |||
| symptoms = [[Skin lesion]], [[nodule]], [[ulceration]] | |||
| complications = [[Metastasis]], [[local recurrence]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic]] | |||
| causes = [[Ultraviolet radiation]], [[genetic mutations]] | |||
| risks = [[Sun exposure]], [[fair skin]], [[family history]] | |||
| diagnosis = [[Biopsy]], [[histopathology]] | |||
| differential = [[Scar]], [[neurofibroma]], [[sclerosing nevus]] | |||
| treatment = [[Surgical excision]], [[radiation therapy]], [[immunotherapy]] | |||
| prognosis = Variable, depends on stage and treatment | |||
| frequency = Rare, accounts for 1-4% of [[melanoma]] cases | |||
}} | |||
{{DISPLAYTITLE:Desmoplastic Melanoma}} | {{DISPLAYTITLE:Desmoplastic Melanoma}} | ||
'''Desmoplastic melanoma''' is a rare subtype of [[melanoma]], a type of [[skin cancer]] that arises from the [[melanocytes]], the cells responsible for producing [[melanin]], the pigment that gives skin its color. This form of melanoma is characterized by a dense fibrous stroma, which can make it difficult to diagnose. | '''Desmoplastic melanoma''' is a rare subtype of [[melanoma]], a type of [[skin cancer]] that arises from the [[melanocytes]], the cells responsible for producing [[melanin]], the pigment that gives skin its color. This form of melanoma is characterized by a dense fibrous stroma, which can make it difficult to diagnose. | ||
== Clinical Features == | == Clinical Features == | ||
Desmoplastic melanoma often presents as a firm, non-pigmented nodule or plaque on the skin. It is most commonly found on sun-exposed areas, particularly the head and neck region of older adults. Unlike other melanomas, desmoplastic melanoma may not exhibit the typical ABCDE characteristics (Asymmetry, Border irregularity, Color variation, Diameter, and Evolving nature) associated with melanoma. | Desmoplastic melanoma often presents as a firm, non-pigmented nodule or plaque on the skin. It is most commonly found on sun-exposed areas, particularly the head and neck region of older adults. Unlike other melanomas, desmoplastic melanoma may not exhibit the typical ABCDE characteristics (Asymmetry, Border irregularity, Color variation, Diameter, and Evolving nature) associated with melanoma. | ||
== Pathology == | == Pathology == | ||
The histological hallmark of desmoplastic melanoma is the presence of spindle-shaped melanocytes within a dense, fibrous stroma. This desmoplastic reaction can make the tumor appear similar to other fibrous tumors, complicating diagnosis. Immunohistochemical staining is often used to differentiate desmoplastic melanoma from other lesions. | The histological hallmark of desmoplastic melanoma is the presence of spindle-shaped melanocytes within a dense, fibrous stroma. This desmoplastic reaction can make the tumor appear similar to other fibrous tumors, complicating diagnosis. Immunohistochemical staining is often used to differentiate desmoplastic melanoma from other lesions. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of desmoplastic melanoma typically involves a combination of clinical examination, dermoscopy, and histopathological analysis. A biopsy is essential for confirming the diagnosis. Due to its atypical presentation, desmoplastic melanoma is often diagnosed at a later stage compared to other melanomas. | Diagnosis of desmoplastic melanoma typically involves a combination of clinical examination, dermoscopy, and histopathological analysis. A biopsy is essential for confirming the diagnosis. Due to its atypical presentation, desmoplastic melanoma is often diagnosed at a later stage compared to other melanomas. | ||
== Treatment == | == Treatment == | ||
The primary treatment for desmoplastic melanoma is surgical excision with clear margins. Due to its propensity for local recurrence, wide local excision is often recommended. Sentinel lymph node biopsy may be considered, although the likelihood of lymphatic spread is lower compared to other melanoma subtypes. Adjuvant therapies, such as radiation or immunotherapy, may be considered in certain cases. | The primary treatment for desmoplastic melanoma is surgical excision with clear margins. Due to its propensity for local recurrence, wide local excision is often recommended. Sentinel lymph node biopsy may be considered, although the likelihood of lymphatic spread is lower compared to other melanoma subtypes. Adjuvant therapies, such as radiation or immunotherapy, may be considered in certain cases. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for desmoplastic melanoma can vary. While it has a lower rate of lymphatic spread, it is more likely to recur locally. Early detection and complete surgical excision are critical for improving outcomes. | The prognosis for desmoplastic melanoma can vary. While it has a lower rate of lymphatic spread, it is more likely to recur locally. Early detection and complete surgical excision are critical for improving outcomes. | ||
== See also == | |||
== | |||
* [[Melanoma]] | * [[Melanoma]] | ||
* [[Skin cancer]] | * [[Skin cancer]] | ||
* [[Melanocytes]] | * [[Melanocytes]] | ||
* [[Immunohistochemistry]] | * [[Immunohistochemistry]] | ||
[[Category:Melanoma]] | [[Category:Melanoma]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Latest revision as of 18:15, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Desmoplastic melanoma | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Skin lesion, nodule, ulceration |
| Complications | Metastasis, local recurrence |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Ultraviolet radiation, genetic mutations |
| Risks | Sun exposure, fair skin, family history |
| Diagnosis | Biopsy, histopathology |
| Differential diagnosis | Scar, neurofibroma, sclerosing nevus |
| Prevention | N/A |
| Treatment | Surgical excision, radiation therapy, immunotherapy |
| Medication | N/A |
| Prognosis | Variable, depends on stage and treatment |
| Frequency | Rare, accounts for 1-4% of melanoma cases |
| Deaths | N/A |
Desmoplastic melanoma is a rare subtype of melanoma, a type of skin cancer that arises from the melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color. This form of melanoma is characterized by a dense fibrous stroma, which can make it difficult to diagnose.
Clinical Features[edit]
Desmoplastic melanoma often presents as a firm, non-pigmented nodule or plaque on the skin. It is most commonly found on sun-exposed areas, particularly the head and neck region of older adults. Unlike other melanomas, desmoplastic melanoma may not exhibit the typical ABCDE characteristics (Asymmetry, Border irregularity, Color variation, Diameter, and Evolving nature) associated with melanoma.
Pathology[edit]
The histological hallmark of desmoplastic melanoma is the presence of spindle-shaped melanocytes within a dense, fibrous stroma. This desmoplastic reaction can make the tumor appear similar to other fibrous tumors, complicating diagnosis. Immunohistochemical staining is often used to differentiate desmoplastic melanoma from other lesions.
Diagnosis[edit]
Diagnosis of desmoplastic melanoma typically involves a combination of clinical examination, dermoscopy, and histopathological analysis. A biopsy is essential for confirming the diagnosis. Due to its atypical presentation, desmoplastic melanoma is often diagnosed at a later stage compared to other melanomas.
Treatment[edit]
The primary treatment for desmoplastic melanoma is surgical excision with clear margins. Due to its propensity for local recurrence, wide local excision is often recommended. Sentinel lymph node biopsy may be considered, although the likelihood of lymphatic spread is lower compared to other melanoma subtypes. Adjuvant therapies, such as radiation or immunotherapy, may be considered in certain cases.
Prognosis[edit]
The prognosis for desmoplastic melanoma can vary. While it has a lower rate of lymphatic spread, it is more likely to recur locally. Early detection and complete surgical excision are critical for improving outcomes.
