Chylothorax

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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W8MD medical weight loss NYC and sleep center NYC

Chylothorax
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Shortness of breath, chest pain, cough, fatigue
Complications	Respiratory failure, infection
Onset	Sudden or gradual
Duration	Variable
Types	N/A
Causes	Trauma, surgery, malignancy, congenital
Risks	Thoracic surgery, lymphoma, tuberculosis
Diagnosis	Chest X-ray, CT scan, thoracentesis
Differential diagnosis	Pleural effusion, pneumothorax, hemothorax
Prevention	N/A
Treatment	Thoracostomy, pleurodesis, dietary modification, surgery
Medication	Octreotide, somatostatin
Prognosis	Variable, depends on underlying cause
Frequency	Rare
Deaths	N/A

Bilateral chylothorax seen on a thoracic MRI

Extensive chylothorax caused by leakage from the thoracic duct

Chest X-ray showing bilateral chylothorax

Chylothorax is a medical condition characterized by the accumulation of lymphatic fluid in the pleural space, the cavity between the lungs and the chest wall. This condition is caused by the disruption or obstruction of the thoracic duct, leading to the leakage of chyle, a milky fluid rich in lipids and lymphocytes, into the pleural space. Chylothorax can result from various causes, including trauma, malignancy, and idiopathic conditions, making its management complex and multifaceted.

Causes

Chylothorax may be classified as traumatic or non-traumatic. Traumatic chylothorax often results from surgical procedures, such as cardiothoracic surgery, or from direct physical injury to the thoracic duct. Non-traumatic causes include malignancies like lymphoma or lung cancer, which can obstruct the thoracic duct, and diseases such as filariasis that affect the lymphatic system. In some cases, the cause of chylothorax remains idiopathic, meaning it is unknown despite thorough investigation.

Symptoms

The symptoms of chylothorax can vary depending on the volume of chyle accumulation. Common symptoms include dyspnea (difficulty breathing), cough, chest pain, and general discomfort. In severe cases, chylothorax can lead to respiratory distress and compromised lung function due to the compression of the lung by the accumulated fluid.

Diagnosis

Diagnosis of chylothorax involves a combination of clinical assessment, imaging studies, and analysis of pleural fluid. Chest X-ray and CT scan are commonly used to visualize fluid accumulation. Confirmatory diagnosis is made by pleural fluid analysis, which shows a milky appearance of the fluid, high triglyceride levels, and the presence of lymphocytes.

Treatment

The treatment of chylothorax aims to relieve symptoms, prevent complications, and address the underlying cause. Initial management often includes thoracentesis, the removal of chyle from the pleural space to alleviate symptoms. Dietary modifications, such as a high-protein, low-fat diet supplemented with medium-chain triglycerides, are recommended to reduce chyle production. In cases where conservative management fails, surgical interventions such as thoracic duct ligation or pleurodesis may be necessary. Advanced therapies, including the use of octreotide and somatostatin analogs, have shown promise in reducing chyle production.

Prognosis

The prognosis of chylothorax varies depending on the underlying cause and the effectiveness of treatment. While traumatic chylothorax has a relatively good prognosis with appropriate management, chylothorax due to malignancy often has a poorer outcome. Early diagnosis and comprehensive management are crucial to improving the prognosis and quality of life for patients with chylothorax.

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