Xanthoma striatum palmare: Difference between revisions
From WikiMD's Wellness Encyclopedia
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{Infobox medical condition | |||
| name = Xanthoma striatum palmare | |||
| synonyms = | |||
| image = | |||
| image_size = | |||
| alt = | |||
| caption = | |||
| specialty = [[Dermatology]], [[Endocrinology]] | |||
| symptoms = Yellowish [[plaques]] on the [[palms]] | |||
| complications = | |||
| onset = | |||
| duration = | |||
| types = | |||
| causes = [[Hyperlipoproteinemia]] | |||
| risks = | |||
| diagnosis = [[Physical examination]], [[Lipid profile]] | |||
| differential = | |||
| prevention = | |||
| treatment = [[Lipid-lowering agents]] | |||
| medication = [[Statins]], [[Fibrates]] | |||
| prognosis = | |||
| frequency = Rare | |||
}} | |||
{{Short description|A rare type of xanthoma associated with hyperlipoproteinemia}} | {{Short description|A rare type of xanthoma associated with hyperlipoproteinemia}} | ||
{{Medical resources}} | {{Medical resources}} | ||
'''Xanthoma striatum palmare''' is a rare dermatological condition characterized by the presence of yellowish-orange deposits on the palms of the hands. These deposits are due to the accumulation of lipids, specifically cholesterol and triglycerides, within the skin. Xanthoma striatum palmare is often associated with underlying lipid metabolism disorders, particularly type III [[hyperlipoproteinemia]]. | '''Xanthoma striatum palmare''' is a rare dermatological condition characterized by the presence of yellowish-orange deposits on the palms of the hands. These deposits are due to the accumulation of lipids, specifically cholesterol and triglycerides, within the skin. Xanthoma striatum palmare is often associated with underlying lipid metabolism disorders, particularly type III [[hyperlipoproteinemia]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Xanthomas are formed when lipids accumulate in the skin, often due to elevated levels of lipoproteins in the blood. In the case of xanthoma striatum palmare, the condition is closely linked to type III hyperlipoproteinemia, also known as dysbetalipoproteinemia. This disorder is characterized by the accumulation of intermediate-density lipoproteins (IDL) due to a defect in the apolipoprotein E (ApoE) receptor binding. The impaired clearance of these lipoproteins leads to their deposition in various tissues, including the skin. | Xanthomas are formed when lipids accumulate in the skin, often due to elevated levels of lipoproteins in the blood. In the case of xanthoma striatum palmare, the condition is closely linked to type III hyperlipoproteinemia, also known as dysbetalipoproteinemia. This disorder is characterized by the accumulation of intermediate-density lipoproteins (IDL) due to a defect in the apolipoprotein E (ApoE) receptor binding. The impaired clearance of these lipoproteins leads to their deposition in various tissues, including the skin. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with xanthoma striatum palmare typically present with: | Patients with xanthoma striatum palmare typically present with: | ||
* Yellowish-orange streaks or patches on the palms, particularly along the lines of the skin. | * Yellowish-orange streaks or patches on the palms, particularly along the lines of the skin. | ||
* These lesions are often symmetrical and can vary in size. | * These lesions are often symmetrical and can vary in size. | ||
* The condition may be accompanied by other types of xanthomas, such as [[tuberous xanthomas]] or [[xanthelasma]]. | * The condition may be accompanied by other types of xanthomas, such as [[tuberous xanthomas]] or [[xanthelasma]]. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of xanthoma striatum palmare is primarily clinical, based on the characteristic appearance of the lesions. However, laboratory tests are essential to confirm the underlying lipid disorder. These tests may include: | The diagnosis of xanthoma striatum palmare is primarily clinical, based on the characteristic appearance of the lesions. However, laboratory tests are essential to confirm the underlying lipid disorder. These tests may include: | ||
* Lipid profile to assess levels of cholesterol, triglycerides, and lipoproteins. | * Lipid profile to assess levels of cholesterol, triglycerides, and lipoproteins. | ||
* Genetic testing for mutations in the [[Apolipoprotein E]] gene. | * Genetic testing for mutations in the [[Apolipoprotein E]] gene. | ||
==Management== | ==Management== | ||
The management of xanthoma striatum palmare involves treating the underlying lipid disorder. This may include: | The management of xanthoma striatum palmare involves treating the underlying lipid disorder. This may include: | ||
* Dietary modifications to reduce cholesterol and triglyceride intake. | * Dietary modifications to reduce cholesterol and triglyceride intake. | ||
* Pharmacological therapy with lipid-lowering agents such as [[statins]], [[fibrates]], or [[niacin]]. | * Pharmacological therapy with lipid-lowering agents such as [[statins]], [[fibrates]], or [[niacin]]. | ||
* Regular monitoring of lipid levels to assess treatment efficacy. | * Regular monitoring of lipid levels to assess treatment efficacy. | ||
==Prognosis== | ==Prognosis== | ||
With appropriate management of the underlying lipid disorder, the prognosis for patients with xanthoma striatum palmare is generally good. The skin lesions may regress with effective lipid control, although this can take several months to years. | With appropriate management of the underlying lipid disorder, the prognosis for patients with xanthoma striatum palmare is generally good. The skin lesions may regress with effective lipid control, although this can take several months to years. | ||
==Related pages== | ==Related pages== | ||
* [[Xanthoma]] | * [[Xanthoma]] | ||
| Line 35: | Line 49: | ||
* [[Apolipoprotein E]] | * [[Apolipoprotein E]] | ||
* [[Dysbetalipoproteinemia]] | * [[Dysbetalipoproteinemia]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Metabolic disorders]] | [[Category:Metabolic disorders]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
Latest revision as of 23:42, 3 April 2025
| Xanthoma striatum palmare | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | Dermatology, Endocrinology |
| Symptoms | Yellowish plaques on the palms |
| Complications | |
| Onset | |
| Duration | |
| Types | |
| Causes | Hyperlipoproteinemia |
| Risks | |
| Diagnosis | Physical examination, Lipid profile |
| Differential diagnosis | |
| Prevention | |
| Treatment | Lipid-lowering agents |
| Medication | Statins, Fibrates |
| Prognosis | |
| Frequency | Rare |
| Deaths | N/A |
A rare type of xanthoma associated with hyperlipoproteinemia
Xanthoma striatum palmare is a rare dermatological condition characterized by the presence of yellowish-orange deposits on the palms of the hands. These deposits are due to the accumulation of lipids, specifically cholesterol and triglycerides, within the skin. Xanthoma striatum palmare is often associated with underlying lipid metabolism disorders, particularly type III hyperlipoproteinemia.
Pathophysiology[edit]
Xanthomas are formed when lipids accumulate in the skin, often due to elevated levels of lipoproteins in the blood. In the case of xanthoma striatum palmare, the condition is closely linked to type III hyperlipoproteinemia, also known as dysbetalipoproteinemia. This disorder is characterized by the accumulation of intermediate-density lipoproteins (IDL) due to a defect in the apolipoprotein E (ApoE) receptor binding. The impaired clearance of these lipoproteins leads to their deposition in various tissues, including the skin.
Clinical Presentation[edit]
Patients with xanthoma striatum palmare typically present with:
- Yellowish-orange streaks or patches on the palms, particularly along the lines of the skin.
- These lesions are often symmetrical and can vary in size.
- The condition may be accompanied by other types of xanthomas, such as tuberous xanthomas or xanthelasma.
Diagnosis[edit]
The diagnosis of xanthoma striatum palmare is primarily clinical, based on the characteristic appearance of the lesions. However, laboratory tests are essential to confirm the underlying lipid disorder. These tests may include:
- Lipid profile to assess levels of cholesterol, triglycerides, and lipoproteins.
- Genetic testing for mutations in the Apolipoprotein E gene.
Management[edit]
The management of xanthoma striatum palmare involves treating the underlying lipid disorder. This may include:
- Dietary modifications to reduce cholesterol and triglyceride intake.
- Pharmacological therapy with lipid-lowering agents such as statins, fibrates, or niacin.
- Regular monitoring of lipid levels to assess treatment efficacy.
Prognosis[edit]
With appropriate management of the underlying lipid disorder, the prognosis for patients with xanthoma striatum palmare is generally good. The skin lesions may regress with effective lipid control, although this can take several months to years.
