Non-ossifying fibroma: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{Short description|A benign bone tumor}} | |||
{{Use dmy dates|date=October 2023}} | |||
'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons. | |||
Non-ossifying | |||
== | ==Pathophysiology== | ||
Non-ossifying fibromas are composed of fibrous tissue and are considered a type of [[fibrous cortical defect]]. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the [[cortex]] of the bone. | |||
== | ==Clinical Presentation== | ||
Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause [[pain]] or [[pathological fracture]]s, especially if they weaken the structural integrity of the bone. | |||
== | ==Diagnosis== | ||
Diagnosis is primarily made through imaging studies. On [[X-ray]], non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the [[femur]] or [[tibia]]. | |||
== | [[File:NOF_1.jpg|Non-ossifying fibroma|thumb|right]] | ||
Advanced imaging techniques such as [[CT scan]] or [[MRI]] can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim. | |||
[[File:MaturenonossifyingfibromaCT.PNG|Mature non-ossifying fibroma CT|thumb|left]] | |||
==Treatment== | |||
In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture. | |||
==Prognosis== | |||
The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare. | |||
==Related pages== | |||
* [[Bone tumor]] | * [[Bone tumor]] | ||
* [[ | * [[Fibrous dysplasia]] | ||
* [[ | * [[Osteochondroma]] | ||
[[Category: | [[Category:Benign neoplasms]] | ||
[[Category:Bone | [[Category:Bone disorders]] | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
Revision as of 18:58, 23 March 2025
A benign bone tumor
Non-ossifying fibroma (NOF) is a benign bone tumor that typically occurs in the metaphysis of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on X-rays taken for other reasons.
Pathophysiology
Non-ossifying fibromas are composed of fibrous tissue and are considered a type of fibrous cortical defect. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the cortex of the bone.
Clinical Presentation
Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause pain or pathological fractures, especially if they weaken the structural integrity of the bone.
Diagnosis
Diagnosis is primarily made through imaging studies. On X-ray, non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the femur or tibia.
Advanced imaging techniques such as CT scan or MRI can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim.
Treatment
In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture.
Prognosis
The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare.
