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'''Calcium oxalate''' is a chemical compound that forms needle-shaped crystals, a common constituent of human kidney stones, and is also found in the stems, leaves, and roots of some plants. It is a salt of oxalic acid and calcium, with the chemical formula CaC₂O₄. This compound is of significant interest in various fields including medicine, botany, and nutrition due to its implications in health and plant physiology.
==Calcium Oxalate==


==Formation and Structure==
[[File:Calcium_oxalate_resonance.png|thumb|right|Resonance structures of calcium oxalate]]
Calcium oxalate is formed by the combination of calcium ions and oxalate ions in solution. In the human body, it is a major component of the most common type of kidney stones. The formation of these crystals in the kidneys can lead to kidney stone formation when the crystals grow larger and are not flushed out of the kidney. In plants, calcium oxalate crystals are produced as a byproduct of metabolism and serve various functions including calcium regulation and protection against herbivory.


==Types of Calcium Oxalate Crystals==
'''Calcium oxalate''' is a chemical compound with the formula CaC₂O₄. It is a salt of [[calcium]] and [[oxalic acid]], and it occurs naturally in many plants and animals. Calcium oxalate is known for its role in the formation of [[kidney stones]] and is also found in certain foods and plants.
There are two main forms of calcium oxalate crystals found in nature: monohydrate (whewellite) and dihydrate (weddellite). Whewellite crystals are more commonly associated with kidney stones in humans, while weddellite crystals are often found in plants.


==Health Implications==
==Structure and Properties==
In humans, the accumulation of calcium oxalate crystals in the kidneys can lead to the formation of kidney stones, a condition known as nephrolithiasis. These stones can cause severe pain, urinary tract infections, and even kidney damage if not properly managed. Dietary factors, hydration status, and certain genetic predispositions can influence the formation of calcium oxalate stones.


==Diet and Prevention==
Calcium oxalate exists in several hydrate forms, including the monohydrate, dihydrate, and trihydrate. The monohydrate form, known as whewellite, is the most common form found in kidney stones. The dihydrate form is known as weddellite, and the trihydrate form is called caoxite.
Diet plays a crucial role in the management and prevention of calcium oxalate kidney stones. Foods high in oxalates, such as spinach, rhubarb, and nuts, should be consumed in moderation by individuals prone to stone formation. Adequate hydration is also essential to dilute the urine and promote the excretion of oxalates and calcium.


==Plant Physiology==
[[File:246802-ICSDox.png|thumb|left|Crystal structure of calcium oxalate]]
In plants, calcium oxalate crystals serve several functions, including the storage of calcium, detoxification of oxalate, and defense against herbivores. The presence of these crystals can make certain plants, like the dumb cane (Dieffenbachia) and rhubarb leaves, toxic to humans and animals if ingested.


==Treatment==
The compound is poorly soluble in water, which contributes to its tendency to precipitate and form stones in the urinary tract. Calcium oxalate crystals can appear in various shapes, including needle-like, dumbbell-shaped, or envelope-shaped, depending on the conditions of formation.
The treatment of calcium oxalate kidney stones involves pain management, increasing fluid intake, and, in some cases, medical procedures to remove or break down the stones. Medications may also be prescribed to prevent further stone formation.


==Research and Studies==
==Occurrence==
Ongoing research in the field of urology and nephrology focuses on understanding the mechanisms of calcium oxalate crystal formation and identifying potential therapeutic targets to prevent kidney stone formation. Studies on plant calcium oxalate crystals aim to elucidate their roles in plant physiology and their impact on plant-animal interactions.


[[Category:Chemical compounds]]
Calcium oxalate is found in many plants, where it serves as a defense mechanism against herbivory. Plants such as [[rhubarb]], [[spinach]], and [[beetroot]] contain high levels of oxalates. In animals, calcium oxalate is a common component of kidney stones, which can cause significant health issues if not managed properly.
 
[[File:Surface_of_a_kidney_stone.jpg|thumb|right|Surface of a kidney stone composed of calcium oxalate]]
 
==Role in Kidney Stones==
 
Calcium oxalate is the most common constituent of kidney stones, accounting for about 80% of cases. Stones form when there is an imbalance in the concentration of calcium and oxalate in the urine, leading to precipitation and crystallization. Factors such as dehydration, dietary habits, and genetic predisposition can influence stone formation.
 
==Detection and Analysis==
 
Calcium oxalate crystals can be detected in urine samples using microscopy. They are often identified by their characteristic shapes and birefringence under polarized light.
 
[[File:Calcium_oxalate_crystals_in_urine.jpg|thumb|left|Calcium oxalate crystals in urine]]
 
==Prevention and Treatment==
 
Preventing calcium oxalate stone formation involves maintaining adequate hydration, reducing dietary oxalate intake, and managing calcium levels. In some cases, medications may be prescribed to alter urine chemistry and reduce stone formation risk.
 
==Related Pages==
 
* [[Kidney stone]]
* [[Oxalic acid]]
* [[Calcium]]
* [[Urolithiasis]]
 
[[Category:Calcium compounds]]
[[Category:Oxalates]]
[[Category:Kidney stones]]
[[Category:Kidney stones]]
[[Category:Urology]]
[[Category:Nephrology]]
[[Category:Plant physiology]]
{{medicine-stub}}
<gallery>
File:Calcium_oxalate_resonance.png|Calcium oxalate
File:246802-ICSDox.png|Calcium oxalate
File:Surface_of_a_kidney_stone.jpg|Calcium oxalate
File:Calcium_oxalate_crystals_in_urine.jpg|Calcium oxalate
File:Calcium_oxalate_crystals_(urine)_-_kalsiyum_oksalat_kristalleri_(idrar)_-_01.png|Calcium oxalate
File:Calcium_oxalate_crystals_(urine)_-_kalsiyum_oksalat_kristalleri_(idrar)_-_02.png|Calcium oxalate
File:Calcium_Oxalate_Detail.png|Calcium oxalate
File:Urine_crystals_comparison.png|Calcium oxalate
File:Histopathology_of_a_breast_cyst_with_calcium_oxalate_crystals,_annotated.jpg|Calcium oxalate
File:Spiculated_kidney_stone.jpg|Calcium oxalate
File:Head_of_a_morning_star.jpg|Calcium oxalate
</gallery>
<gallery>
File:Surface_of_a_kidney_stone.jpg|Surface of a kidney stone
File:Calcium_oxalate_crystals_in_urine.jpg|Calcium oxalate crystals in urine
File:Calcium_oxalate_crystals_(urine)_-_kalsiyum_oksalat_kristalleri_(idrar)_-_01.png|Calcium oxalate crystals (urine) - kalsiyum oksalat kristalleri (idrar) - 01
File:Calcium_oxalate_crystals_(urine)_-_kalsiyum_oksalat_kristalleri_(idrar)_-_02.png|Calcium oxalate crystals (urine) - kalsiyum oksalat kristalleri (idrar) - 02
File:Calcium_Oxalate_Detail.png|Calcium Oxalate Detail
File:Urine_crystals_comparison.png|Urine crystals comparison
File:Histopathology_of_a_breast_cyst_with_calcium_oxalate_crystals,_annotated.jpg|Histopathology of a breast cyst with calcium oxalate crystals, annotated
</gallery>

Latest revision as of 10:56, 23 March 2025

Calcium Oxalate[edit]

Resonance structures of calcium oxalate

Calcium oxalate is a chemical compound with the formula CaC₂O₄. It is a salt of calcium and oxalic acid, and it occurs naturally in many plants and animals. Calcium oxalate is known for its role in the formation of kidney stones and is also found in certain foods and plants.

Structure and Properties[edit]

Calcium oxalate exists in several hydrate forms, including the monohydrate, dihydrate, and trihydrate. The monohydrate form, known as whewellite, is the most common form found in kidney stones. The dihydrate form is known as weddellite, and the trihydrate form is called caoxite.

Crystal structure of calcium oxalate

The compound is poorly soluble in water, which contributes to its tendency to precipitate and form stones in the urinary tract. Calcium oxalate crystals can appear in various shapes, including needle-like, dumbbell-shaped, or envelope-shaped, depending on the conditions of formation.

Occurrence[edit]

Calcium oxalate is found in many plants, where it serves as a defense mechanism against herbivory. Plants such as rhubarb, spinach, and beetroot contain high levels of oxalates. In animals, calcium oxalate is a common component of kidney stones, which can cause significant health issues if not managed properly.

Surface of a kidney stone composed of calcium oxalate

Role in Kidney Stones[edit]

Calcium oxalate is the most common constituent of kidney stones, accounting for about 80% of cases. Stones form when there is an imbalance in the concentration of calcium and oxalate in the urine, leading to precipitation and crystallization. Factors such as dehydration, dietary habits, and genetic predisposition can influence stone formation.

Detection and Analysis[edit]

Calcium oxalate crystals can be detected in urine samples using microscopy. They are often identified by their characteristic shapes and birefringence under polarized light.

Calcium oxalate crystals in urine

Prevention and Treatment[edit]

Preventing calcium oxalate stone formation involves maintaining adequate hydration, reducing dietary oxalate intake, and managing calcium levels. In some cases, medications may be prescribed to alter urine chemistry and reduce stone formation risk.

Related Pages[edit]