Progestin-induced virilization

Progestin-induced virilization is a rare condition that occurs when female fetuses are exposed to progestins, a type of synthetic progesterone, during the first trimester of pregnancy. This exposure can lead to the development of male physical characteristics (virilization) in female fetuses.

Causes

Progestin-induced virilization is caused by exposure to progestins during the first trimester of pregnancy. Progestins are synthetic forms of progesterone, a hormone that plays a key role in the menstrual cycle and pregnancy. They are often used in hormonal contraceptives and to treat conditions such as abnormal uterine bleeding and endometriosis.

Symptoms

The symptoms of progestin-induced virilization can vary, but may include:

• Enlarged clitoris (clitoromegaly)
• Partial fusion of the labia
• Unusual facial features
• Deep voice
• Increased body hair

Diagnosis

Diagnosis of progestin-induced virilization can be challenging, as the condition is rare and the symptoms can vary. A detailed medical history, physical examination, and laboratory tests may be used to make a diagnosis.

Treatment

Treatment for progestin-induced virilization is typically focused on managing the symptoms. This may include surgery to reduce the size of the clitoris and reconstruct the labia, hormone therapy, and psychological support.

See also

• Virilization
• Progestin
• Progesterone
• Clitoromegaly

References

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