Epithelioid trophoblastic tumour

Epithelioid trophoblastic tumour
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Synonyms
Pronounce
Field	oncology
Symptoms
Complications
Onset
Duration
Types
Causes
Risks
Diagnosis
Differential diagnosis
Prevention
Treatment
Medication
Prognosis
Frequency
Deaths

Epithelioid trophoblastic tumor (ETT) is a gestational trophoblastic disease with about 110 case reports in the literature. It is a trophoblastic tumor of neoplastic chorionic type associated with the intermediate trophoblast.

Signs and symptoms

• Vaginal bleeding: The most common presenting symptom is vaginal bleeding, which is associated with mild elevation of serum β hCG (< 2,500 IU/l)
• Amenorrhea.

<ref>http://www.pathologyoutlines.com/topic/placentaETT.html clinical features</ref>

Morphology

Gross appearance

• There is deep infiltration of the surrounding structures by cystic hemorrhagic masses or discrete nodules.
• Necrosis is present with white to tan-brown cut surface with hemorrhage.
• Ulceration (common finding)
• Fistula (common finding)

Microscopic appearance

• Nodular, well circumscribed, focal infiltrative at the periphery.
• Uniform, mononucleate tumor cells are arranged in nests and cords.
• Tumor nests are associated with osinophilic, fibrillar, hyaline-like material.
• Extensive necrosis with irregular contours.
• Calcification (common finding)
• Metaplastic endocervical or endometrial surface epithelium into squamous-like epithelium.

Locations

Common locations are:

• Uterus
  • Lower uterine segment (40%)
  • Cervix (31% of cases)
• Lungs (19% of cases)

They may rarely develop in

• Vagina
• Broad ligament
• Fallopian tubes
• Other pelvic organs

<ref name="ETT">Epithelioid trophoblastic tumor [1]. Pathology outlines, August 26, 2017.</ref>

Treatment

Epithelioid trophoblastic tumors (ETTs) are resistant to chemotherapy. Stage I disease is treated with hysterectomy, while metastatic disease is treated with surgery and chemotherapy. <ref name="ETT">Epithelioid trophoblastic tumor [2]. Pathology outlines, August 26, 2017.</ref>

Prognosis

Metastasis occur in 25% of cases and 10% die of the disease. Mitotic count of > 6/10HPF is an unfavorable prognostic factor. <ref name="ETT">Epithelioid trophoblastic tumor [3]. Pathology outlines, August 26, 2017.</ref>

References

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