Lipodystrophy

Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. Adipose tissue, or fat, is a crucial part of the body's system, playing a significant role in storing energy and regulating metabolism. Lipodystrophy can be either inherited or acquired. The term lipodystrophy, which literally means abnormal fat, is often used to refer specifically to the syndrome that affects people who are on long-term antiretroviral therapy (ART) for HIV.

Types of Lipodystrophy

There are several types of lipodystrophy, including:

• Congenital generalized lipodystrophy, also known as Berardinelli-Seip congenital lipodystrophy. This is a rare condition that is present from birth and affects both males and females.

• Familial partial lipodystrophy, which affects the limbs and is inherited.

• Acquired partial lipodystrophy, which is more common in females and usually develops during childhood.

• HIV-associated lipodystrophy, which can occur in people who are taking certain antiretroviral medications for HIV.

Symptoms

The symptoms of lipodystrophy can vary depending on the type and severity of the condition. They can include:

• Loss of subcutaneous fat
• Accumulation of fat in unusual areas, such as the neck and abdomen
• High levels of triglycerides in the blood
• Insulin resistance
• Diabetes
• Hepatomegaly (enlarged liver)
• Polycystic ovary syndrome in women

Treatment

Treatment for lipodystrophy typically involves managing the symptoms and complications of the condition. This can include:

• Dietary changes to manage diabetes and high triglyceride levels
• Medications to reduce insulin resistance and high triglyceride levels
• Plastic surgery to remove excess fat in some cases

See also

• Adipose tissue
• Antiretroviral therapy
• HIV
• Insulin resistance
• Diabetes
• Hepatomegaly
• Polycystic ovary syndrome

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