Pancreaticobiliary maljunction

Pancreaticobiliary maljunction (PBM) is a rare congenital anomaly characterized by a union of the pancreatic and biliary ducts located outside the duodenal wall. This condition is associated with an increased risk of biliary tract cancer and gallbladder cancer.

Anatomy

The pancreas and biliary tract are two separate systems in the body that aid in digestion. The pancreas produces enzymes that help break down food, while the biliary tract produces bile that helps the body absorb fats. In individuals with PBM, these two systems are connected, which can lead to various health complications.

Pathophysiology

In PBM, the junction of the pancreatic and biliary ducts is located outside the duodenal wall, usually within the head of the pancreas. This abnormal junction allows pancreatic juice to reflux into the biliary tract, leading to inflammation, increased pressure, and potential for malignancy.

Symptoms

Symptoms of PBM can vary greatly depending on the individual and the severity of the condition. Some individuals may experience no symptoms, while others may experience abdominal pain, jaundice, or recurrent pancreatitis.

Diagnosis

Diagnosis of PBM is typically made through imaging studies such as magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), or ultrasound. These imaging studies can help visualize the pancreatic and biliary ducts and identify any abnormalities.

Treatment

Treatment for PBM typically involves surgery to correct the abnormal junction of the pancreatic and biliary ducts. This can help prevent complications such as biliary tract cancer and gallbladder cancer.

See also

• Pancreas
• Biliary tract
• Gallbladder cancer
• Biliary tract cancer

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