PIAS3

PIAS3 is a protein that in humans is encoded by the PIAS3 gene. It has been identified as a specific inhibitor of STAT3 and is involved in various biological processes.

Function

PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. These proteins function as SUMO E3 ligases and regulate the activity of various transcription factors. PIAS3 specifically inhibits STAT3 transcriptional activity by blocking its DNA binding activity. This protein is found in the cytoplasm and can form a complex with UBE2I/UBC9. It also modulates STAT3 activation in response to a number of different stimuli, including Interleukin-6 and Epidermal Growth Factor.

Clinical significance

Alterations in the PIAS3 gene have been associated with various diseases. For example, decreased expression of PIAS3 has been observed in glioblastoma cells, suggesting a potential role in the pathogenesis of this type of brain tumor. Additionally, PIAS3 has been implicated in the regulation of insulin signaling and glucose homeostasis, and alterations in this gene may contribute to the development of type 2 diabetes.

See also

• Protein inhibitor of activated STAT
• STAT3
• SUMO E3 ligases
• Interleukin-6
• Epidermal Growth Factor
• Glioblastoma
• Insulin
• Type 2 diabetes

References

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External links

• PIAS3 at the National Center for Biotechnology Information

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