OR5D18

OR5D18 is a gene that encodes a protein in humans. The protein is a member of the olfactory receptor family, which is involved in the detection of smell.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific function of OR5D18 is not well understood, mutations in olfactory receptor genes, including OR5D18, have been associated with various diseases. For example, a study found that mutations in certain olfactory receptor genes were associated with congenital anosmia, a condition characterized by a complete inability to smell.

See also

• Olfactory receptor
• G protein-coupled receptor
• Congenital anosmia

References

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External links

• OR5D18 at NCBI
• OR5D18 at GeneCards

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