OR5W2

OR5W2 is a gene that encodes a protein in humans. It is also known as olfactory receptor, family 5, subfamily W, member 2. The OR5W2 gene is part of the olfactory receptor gene family, which is the largest gene family in the genome. The family members are G-protein coupled receptors that respond to smell and taste stimuli and are divided into a main group, intermediate group, and several outlier groups.

Function

The OR5W2 gene is a member of the olfactory receptor family of genes. Olfactory receptors are responsible for the detection of odor molecules in the nose, which is the first step in the perception of smell. The receptors are located on the cilia of the olfactory sensory neurons in the nose. When an odor molecule binds to an olfactory receptor, it triggers a nerve impulse that is transmitted to the brain, where it is interpreted as a specific smell.

Structure

The OR5W2 gene is located on chromosome 11 in humans. It spans approximately 1 kilobase and consists of a single exon. The OR5W2 protein is a member of the class A rhodopsin-like family of G-protein coupled receptors. It is composed of seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus.

Clinical Significance

While the exact role of OR5W2 in human health and disease is not fully understood, it is thought to play a role in the perception of smell. Mutations in the OR5W2 gene could potentially lead to a reduced sense of smell, a condition known as anosmia. However, more research is needed to confirm this hypothesis and to understand the potential implications of OR5W2 mutations in other health conditions.

See Also

• Olfactory receptor
• Anosmia
• G-protein coupled receptor

References

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