Leukotriene B4 receptor 2

Leukotriene B4 receptor 2

The Leukotriene B4 receptor 2, also known as BLT2, is a G protein-coupled receptor that plays a crucial role in the immune response and inflammation. It is a member of the leukotriene receptor family and is primarily expressed in immune cells, such as neutrophils, macrophages, and dendritic cells.

Structure

The BLT2 receptor is encoded by the LTB4R2 gene, which is located on chromosome 14 in humans. It consists of 7 transmembrane domains and an extracellular N-terminus. The receptor undergoes conformational changes upon binding to its ligand, leukotriene B4 (LTB4), which activates downstream signaling pathways.

Function

The main function of the BLT2 receptor is to mediate the effects of LTB4, a potent lipid mediator involved in the recruitment and activation of immune cells. Upon binding to BLT2, LTB4 triggers a cascade of intracellular events, leading to the activation of various signaling pathways, including the MAPK and PI3K/Akt pathways.

Activation of the BLT2 receptor promotes the migration of immune cells to sites of inflammation, enhances phagocytosis, and stimulates the production of pro-inflammatory cytokines. Additionally, BLT2 has been implicated in the regulation of cell proliferation, angiogenesis, and tissue remodeling.

Clinical Significance

Dysregulation of the BLT2 receptor has been associated with several inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. Inhibition of BLT2 signaling has shown promise as a therapeutic strategy for these conditions.

See Also

• Leukotriene B4 receptor 1
• Leukotriene
• G protein-coupled receptor

References

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