KCNE5

KCNE5 is a gene that in humans encodes a member of the potassium channel, voltage-gated, Isk-related subfamily. This member is a type I membrane protein, and is a beta subunit that assembles with a alpha subunit to form a potassium channel. This heteromeric channel may be involved in several cellular processes, including regulation of heartbeat and neuronal excitability.

Function

The KCNE5 gene encodes a member of the KCNE family of voltage-gated potassium channel subunits. These proteins are thought to inhibit channel activity by modulating the gating kinetics and enhancing the stability of the channel complex. They are integral membrane proteins that assemble with the KvLQT1 protein to form the Iks channel. This channel plays a crucial role in the cardiac action potential.

Clinical significance

Mutations in the KCNE5 gene have been associated with arrhythmia, specifically atrial fibrillation. This is a common heart rhythm disorder that can lead to stroke, heart failure, and other heart-related complications.

See also

• Voltage-gated potassium channel
• KvLQT1
• Atrial fibrillation

References

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External links

• KCNE5 at the National Center for Biotechnology Information

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