Isoxazole

Isoxazole is an organic compound and a heterocyclic compound consisting of a five-membered ring that contains an oxygen atom, a nitrogen atom, and three carbon atoms. The compound is isomeric with oxazole.

Structure and synthesis

Isoxazole has a planar structure with the oxygen atom and the nitrogen atom adjacent to each other. The compound can be synthesized through the reaction of hydroxylamine with alpha,beta-unsaturated carbonyl compounds.

Properties

Isoxazole is a colorless liquid at room temperature. It has a boiling point of 34-35 °C at 9 mmHg and a density of 1.071 g/mL at 25 °C. The compound is soluble in water and most organic solvents.

Applications

Isoxazole and its derivatives have a wide range of applications in the field of medicine and agriculture. They are used as building blocks in the synthesis of various pharmaceutical drugs and agrochemicals. Some isoxazole derivatives have shown anti-inflammatory, analgesic, antipyretic, and antibacterial activities.

Safety

Isoxazole is a flammable liquid and its vapors can form explosive mixtures with air. The compound can cause irritation to the eyes, skin, and respiratory tract. It is recommended to handle isoxazole with appropriate protective equipment and in a well-ventilated area.

See also

• Oxazole
• Furazan
• Pyrazole

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