IKK2

IKK2 is a protein that in humans is encoded by the IKBKB gene. IKK2, also known as IκB kinase beta, is part of the IKK complex and plays a crucial role in the NF-κB signaling pathway. This pathway is involved in many cellular processes, including inflammation, immunity, cell survival, and proliferation.

Function

IKK2 is a component of the IKK complex, which consists of two catalytic subunits, IKK1 (also known as IKKα) and IKK2 (also known as IKKβ), and a regulatory subunit, NEMO (also known as IKKγ). The IKK complex phosphorylates inhibitors of NF-κB (IκBs), leading to their degradation and the release of NF-κB. The free NF-κB then translocates to the nucleus and activates the transcription of various genes involved in inflammation, immunity, cell survival, and proliferation.

Clinical significance

Mutations in the IKBKB gene that encodes IKK2 have been associated with immunodeficiency syndromes. These mutations can lead to a decrease in IKK2 activity, resulting in impaired NF-κB activation and a subsequent decrease in immune response.

In addition, IKK2 has been implicated in the pathogenesis of various diseases, including cancer, autoimmune diseases, and inflammatory diseases. Therefore, IKK2 is considered a potential therapeutic target for these diseases.

See also

• IKK1
• IKK complex
• NF-κB
• Immunodeficiency
• Cancer
• Autoimmune diseases
• Inflammatory diseases

References

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