IL18RAP

IL18RAP is a gene that encodes the Interleukin 18 Receptor Accessory Protein in humans. This protein is an essential part of the interleukin 18 (IL18) receptor complex, which plays a crucial role in the immune system's response to infection and disease.

Function

The IL18RAP gene provides instructions for making a protein that forms part of a receptor complex on the surface of certain immune system cells. This complex binds to a molecule called interleukin 18, which is a type of cytokine. Cytokines are a group of proteins that are important for cell signaling in the immune system.

When interleukin 18 binds to its receptor, it triggers a series of chemical signals inside the cell that activate the immune response. This response includes the production of other cytokines that help fight infection and disease.

Clinical significance

Mutations in the IL18RAP gene have been associated with several immune-related conditions. For example, some studies have found a link between variations in this gene and an increased risk of celiac disease, an autoimmune disorder that affects the digestive system. Other research has suggested a possible connection between IL18RAP mutations and susceptibility to Crohn's disease, a type of inflammatory bowel disease.

See also

• Interleukin 18
• Cytokine
• Immune system
• Celiac disease
• Crohn's disease

References

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