GOLM1

GOLM1 (Golgi Membrane Protein 1), also known as GP73, is a protein that in humans is encoded by the GOLM1 gene. It is a resident Golgi type II membrane protein that has been implicated in liver disease and hepatocellular carcinoma (HCC).

Function

GOLM1 is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum (RER) and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene is upregulated in response to viral infection.

Clinical significance

GOLM1 has been identified as a potential serum marker for liver disease and hepatocellular carcinoma (HCC). It is overexpressed in HCC and can be detected in the serum of patients with liver disease, suggesting its potential as a diagnostic and prognostic marker.

See also

• Golgi apparatus
• Hepatocellular carcinoma
• Liver disease

References

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External links

• GOLM1 at the National Center for Biotechnology Information

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