Dose dumping

Dose Dumping

Dose dumping is a phenomenon in pharmacology where a drug is released from its dosage form more rapidly than intended, leading to potentially dangerous consequences. This can occur when the drug is not properly formulated or when certain conditions cause the drug to be released too quickly.

Causes

There are several factors that can contribute to dose dumping, including:

• Inadequate formulation of the drug
• Interaction with other medications
• Alcohol consumption
• Changes in pH levels in the gastrointestinal tract
• Physical damage to the dosage form

Risks

Dose dumping can lead to a rapid increase in drug concentration in the body, which may result in:

• Overdose
• Toxicity
• Adverse drug reactions
• Drug interactions

Prevention

To prevent dose dumping, pharmaceutical companies must ensure that drugs are properly formulated and tested for stability. Patients should also be educated on the importance of taking medications as prescribed and avoiding interactions that may lead to dose dumping.

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