CatSper1

CatSper1 is a protein that in humans is encoded by the CATSPER1 gene. It is a member of the CatSper family, a group of proteins that are essential for sperm function and fertility in males.

Function

CatSper1 is a calcium ion channel protein that is expressed in the testis and is known to play a crucial role in male fertility. It is involved in the regulation of sperm motility and acrosome reaction, both of which are critical for successful fertilization.

Structure

The CatSper1 protein is a transmembrane protein that forms a complex with other CatSper proteins to create a calcium channel in the sperm tail. This channel is responsible for the influx of calcium ions, which is necessary for sperm motility.

Clinical significance

Mutations in the CATSPER1 gene can lead to infertility in males. This is often due to the inability of the sperm to move properly or undergo the acrosome reaction. As such, CATSPER1 is a potential target for the development of male contraceptives and treatments for infertility.

See also

• CatSper
• Calcium channel
• Sperm motility
• Acrosome reaction

References

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