CYP3A7

CYP3A7 is a cytochrome P450 enzyme that is encoded by the CYP3A7 gene in humans. This enzyme is part of the CYP3A family, which is involved in the metabolism of a variety of endogenous and exogenous substances.

Function

CYP3A7 is primarily expressed in the fetus and is involved in the metabolism of steroids, retinoic acid, and other xenobiotics. It is also involved in the hydroxylation of dehydroepiandrosterone (DHEA), a steroid hormone produced in the adrenal glands.

Clinical significance

Alterations in the activity of CYP3A7 can have significant clinical implications. For example, increased activity of this enzyme can lead to decreased levels of certain drugs in the body, potentially reducing their effectiveness. Conversely, decreased activity can lead to increased drug levels, potentially increasing the risk of toxicity.

Genetics

The CYP3A7 gene is located on chromosome 7 and is part of a cluster of cytochrome P450 genes. Variations in this gene can lead to differences in the activity of the CYP3A7 enzyme, which can in turn affect the metabolism of drugs and other substances.

See also

• Cytochrome P450
• CYP3A
• Drug metabolism

References

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