Bombesin-like receptor 3

Bombesin-like receptor 3 (BRS-3) is a protein that in humans is encoded by the BRS3 gene. BRS-3 is a member of the bombesin family of receptors, which also includes gastrin-releasing peptide receptor and neuromedin B receptor.

Function

BRS-3 is a G protein-coupled receptor that is not known to be naturally activated by any endogenous ligand. However, it has been shown to bind synthetic ligands such as bombesin and gastrin-releasing peptide. The function of BRS-3 is not well understood, but it is thought to play a role in energy homeostasis and body weight regulation.

Clinical significance

Mutations in the BRS3 gene have been associated with obesity in humans and mice. In addition, BRS-3 has been implicated in the regulation of insulin secretion and glucose metabolism, suggesting a potential role in the development of type 2 diabetes.

See also

• Bombesin
• G protein-coupled receptor
• Obesity
• Type 2 diabetes

References

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